APOE anticorps

N° du produit ABIN965577

Cet anticorps anti-APOE est un anticorps Souris Monoclonal détectant APOE dans WB, IHC, ELISA et FACS. Adapté pour Humain. Ce Primary Antibody a été cité dans 1 publication.

Aperçu rapide pour APOE anticorps (ABIN965577)

Antigène: APOE (Apolipoprotein E (APOE))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp APOE est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

Clone: 1H4

Détail du produit anti-APOE anticorps

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human ApoE expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application: Western Bloting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
Flow cytometry: 1/200 - 1/400.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Stockage

Format: Liquid

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Références pour anticorps anti-APOE (ABIN965577)

Zintzaras, Kitsios, Triposkiadis, Lau, Raman: "APOE gene polymorphisms and response to statin therapy." dans: The pharmacogenomics journal, Vol. 9, Issue 4, pp. 248-57, (2009) (PubMed).

Détails sur APOE

Antigène: APOE (Apolipoprotein E (APOE))

Autre désignation: ApoE

Sujet: Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptormediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
Tissue specificity: Occurs in all lipoprotein fractions in plasma. It constitutes 10-20% of very low density lipoproteins (VLDL) and 1-2% of high density lipoproteins (HDL). APOE is produced in most organs. Significant quantities are produced in liver, brain, spleen, lung, adrenal, ovary, kidney and muscle.
Synonyms: AD2, LPG, LDLCQ5, MGC1571

Poids moléculaire: 36kDa

ID gène: 348

Pathways: Regulation of Cell Size, Lipid Metabolism